Immunogenicity and reactogenicity of Infanrix™ when co-administered with meningococcal MenACWY-TT conjugate vaccine in toddlers primed with MenHibrix™ and Pediarix™.

Michael Leonardi,Thomas Latiolais,Kwabena Sarpong,Michael Simon,Jerry Twiggs,Paul Lei,Stephen Rinderknecht,Mark Blatter,Veronique Bianco,Yaela Baine,Leonard R Friedland,Carmen Baccarini,Jacqueline M Miller

Vaccine（2015）

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摘要

•Infanrix+MenACWY-TT was investigated in MenHibrix-primed toddlers.•Infanrix+MenACWY-TT was non-inferior to Infanrix alone except for anti-PT/PRN GMCs.•Pertussis GMCs were higher than in infants in whom Infanrix efficacy was shown.•Reactogenicity of co-administered MenACWY-TT+Infanrix was similar to Infanrix alone.•MenHibrix-primed toddlers could be boosted with MenACWY-TT+Infanrix.

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95% CI,ACIP,AE,ATP,Coad,DTaP,DTaP-HBV-IPV,FHA,GMC,Hib-MenCY-TT,Hib-TT,IMD,MenACWY-DT,MenACWY-CRM197,MenACWY-TT,SAE,PRN,PRP,PT,TT,US

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