Molecular mechanisms of repeated social defeat-induced glucocorticoid resistance: Role of microRNA.

•Repeated social stress decreased nr3c1 and fkbp52 expression in splenic macrophage.•Repeated social stress induced epigenetic modification in splenic macrophages.•Repeated social stress significantly decreased the amount of methylated DNA in splenic macrophages.•Repeated social stress induced significantly increased expression of six microRNAs.•microRNA-29b and 340 overexpression diminished GC receptor mRNA expression.