Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic acid.

Melody A Furnari,Constance Lay-Lay Saw, Ah-Ng Kong,George C Wagner

Brain Research Bulletin（2014）

引用 23|浏览11

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摘要

•Nrf2 knockout mice perform similarly to wild type mice in developmental behavioral assays.•Exposure to VPA on postnatal day 14 results in behavioral deficits in wild type and Nrf2 null mice.•Nrf2 knockout mice were more sensitive to VPA as seen in the rotorod and water maze.

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关键词

Nrf2,Knockout mice,Valproic acid,Developmental behavior,Rotorod,Water maze

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