Restoration of IRF1-dependent anticancer effects by MEK inhibition in human cancer cells.

Nader AbuSara,Seyd Razavi,Leena Derwish,Yumiko Komatsu,Maria Licursi,Kensuke Hirasawa

Cancer Letters（2015）

引用 21|浏览7

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摘要

•Ras/MEK activation suppresses the expression of a transcription regulator IRF1.•IRF1 restoration by Ras/MEK inhibition increases transcription of tumor suppressors.•IRF1 plays critical roles in apoptosis induction by MEK inhibition in cancer cells.

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关键词

Ras/MEK,Interferon regulatory factor (IRF1),Apoptosis

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