Associations between the Expression of micro-RNA 214 and clinicopathologic parameters of glioma.

It have been reported that miR-214 reduction facilitates UBC9 expression and is involved in the regulation of glioma cell proliferation. However, the specific role of miR-214 in glioma remains unknown. Thus, we investigated the relationship between expression level of miR-214 and clinico- pathological features and prognosis in patients with glioma in a follow-up of 5years. We used Chi-square tests for the categorical data and Mann Whitney tests for continuous data. Survival time was calculated from the date of glioma diagnosis to the date of death or last follow-up. Survival analysis was estimated using the Kaplan-Meier method, log-rank test, and Cox-proportional hazards regression model. In the present study, we confirmed that the expression level of miR-214 was increased in glioma tissues compared with the non-neoplastic brain tissues. Next, the Kaplan-Meier analysis revealed that glioma patients with high miR-214 expression tend to have poorer overall survival. In addition, the multivariate analysis clearly demonstrated that high miR-214 expression was a statistically significant risk factor affecting overall survival in glioma patients, suggesting that miR-214 upregulation in gliomas is not only in a grade-dependent fashion, it is also a predictor of overall survival. Finally, subgroup analyses showed the significant prognostic value of miR-214 upregulation for glioma patients in those with low and high pathological grade. The results of this study showed that miR-214 was up-regulated in glioma tissues. The expression of miR-214 was associated with the pathological stages of glioma. The results of 5-years follow-up showed that the expression level of miR-214 is a significant prognostic factor for patients with glioma.