Increasing cellular immunogenicity to peptide-based vaccine candidates using a fluorocarbon antigen delivery system.

James N Francis,Jean-François Thaburet,Dominique Bonnet,Philip J Sizer,Carlton B Brown,Bertrand Georges

Vaccine（2015）

引用 5|浏览4

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摘要

•Modification of peptides with a fluorocarbon chain can increase immunogenicity in vivo.•Fluoropeptides show increased responses to cytotoxic and T helper epitopes.•Fluoropeptides show increased resistance to proteolytic degradation.•Fluoropeptides demonstrate prolonged persistence in vivo.

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关键词

Fluoropeptide,Immunogenicity,Vaccine,Delivery system

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