Structural correlates of carrier protein recognition in tetanus toxoid-conjugated bacterial polysaccharide vaccines.
Vaccine(2015)
摘要
•A panel of tetanus toxoid conjugates had structure-mAb binding relationships in common.•A large conjugate size or high saccharide-to-protein ratio does not hinder epitope accessibility.•Saccharide-specific patterns of Trp and epitope accessibility can be localised to the HC domain.
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关键词
Conjugate vaccine,Tetanus toxoid,Chromatography,Fluorescence quenching
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