A critical examination of the mode of action of quinacrine in the reproductive tract in a 2-year rat cancer bioassay and its implications for human clinical use

•Intrauterine quinacrine produced reproductive tract tumors in a two-year rat CaBio.•Organ toxicity demonstrates that the three highest dose groups exceeded the MTD.•Reproductive tract tumors were highly correlated with chronic inflammation.•In rats with no chronic inflammation, quinacrine was not carcinogenic.•The tumors in this CaBio are not relevant to the proposed human use of quinacrine.