Modulation of spinal glial reactivity by intrathecal PPF is not sufficient to inhibit mechanical allodynia induced by nerve crush.

Alessandro Gallo,Andrea Dimiziani,Jonathan Damblon,Benoît Michot,Anne Des Rieux,Marc De Kock,Emmanuel Hermans,Ronald Deumens

Neuroscience Research（2015）

引用 7|浏览6

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摘要

•Pain hypersensitivity after rat nerve crush maintained despite intrathecal PPF.•Functional recovery is only slightly and transiently affected by PPF treatment.•Resolution of pain hypersensitivity is preserved with or without PPF treatment.•Dissociation between microglial modulation and neuropathic pain relief.

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关键词

Nerve injury,Inflammation,Treatment,Spared nerve injury,Pain,Motor function

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