Contribution of the complement Membrane Attack Complex to the bactericidal activity of human serum.

Evelien T M Berends,Sarbani Mohan,Willem R Miellet,Maartje Ruyken,Suzan H M Rooijakkers

Molecular Immunology（2015）

引用 36|浏览16

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摘要

•Gram-negative bacteria that are sensitive to human serum are not necessarily killed by the MAC.•The MAC can kill Gram-negative bacteria at different rates.•Specific MAC-inhibitors, like OmCI, are essential in evaluating the contribution of MAC towards serum bactericidal activity.

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关键词

Serum,Complement,Membrane Attack Complex,Gram-negative bacteria,Bactericidal assay

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