Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay.

Jennifer R Cheung,Donna A Dickinson,Jocelyn Moss,Maik J Schuler,Richard A Spellman,Pamela L Heard

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2015）

引用 19|浏览6

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摘要

•Presents follow-up strategy for in vitro micronucleus positive test results.•Uses histone markers to discriminate aneugens, clastogens and cytotoxicants.•Improves specificity of TK6 in vitro mincronucleus assay.•Identifies novel biomarker for clastogenic compounds.

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关键词

ATM,DAPI,DDR,DSB,EMA,ETO,γH2AX,IVMN,NOS,%RS,p-H3,RIPA,SYTOX,TUN,uH2AX

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