How do viruses control mitochondria-mediated apoptosis?

Simon Neumann,Souhayla El Maadidi,Laura Faletti,Florian Haun,Shirin Labib,Andrea Schejtman,Ulrich Maurer,Christoph Borner

Virus Research（2015）

引用 51|浏览19

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摘要

•Viruses can block extrinsic and intrinsic apoptosis signaling of host cells.•Type I interferon response is used to either eliminate virus or induce host apoptosis.•Viruses can actively engage the apoptotic cell death machinery.•Virally infected cells are killed by CTL and NK cells.

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关键词

RNA viruses,Apoptosis,Bcl-2 family,Death receptor signaling,Intrinsic mitochondrial signaling,Innate immune signaling

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