The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.

Bioorganic & Medicinal Chemistry Letters（2015）

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摘要

Modulating GPR88 activity is suggested to have therapeutic utility in the treatment of CNS disorders, such as schizophrenia. This Letter will describe the discovery and SAR development of a class of potent GPR88 agonists.

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关键词

GPR88,GPC,Agonists,CNS,Schizophrenia

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