Connexin 43 mediates PFOS-induced apoptosis in astrocytes

Li Dong,Xiaoyan Yang,Wen Gu,Kangfeng Zhao, Huizheng Ge,Jianjun Zhou,Xuetao Bai

Chemosphere（2015）

引用 29|浏览11

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摘要

•PFOS induces apoptosis in cortex astrocytes.•Cx43 plays a proapoptotic role in PFOS-induced apoptosis.•PFOS causes oxidative stress and increases ROS accumulation.•PFOS reduces the mitochondria membrane potential in astrocytes.•PFOS initiates mitochondria-mediated apoptosis.

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关键词

Perfluorooctane sulfonate,Connexin 43,Apoptosis,Reactive oxygen species,Neurotoxicity

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