Expression status of candidate genes in mesothelioma tissues and cell lines

Ombretta Melaiu,Erika Melissari,Luciano Mutti,Elisa Bracci,Chiara De Santi,Caterina Iofrida,Manuela Di Russo,Alfonso Cristaudo,Alessandra Bonotti,Monica Cipollini,Sonia I. Garritano,Rudy Foddis,Marco Lucchi,Silvia Pellegrini,Federica Gemignani,Stefano Landi

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2015）

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摘要

•To shed light on the expression status of genes potentially involved in MPM.•Analysis of a large panel of mRNA markers in MPM patients’ tissues and in MPM cell lines.•Identification of 59 differentially expressed genes between MPM and normal pleura.•Identification of BIRC5, DSP, NME2, and THBS2 as putative prognostic markers for MPM.•Importance of cell–cell and cell–matrix interactions in MPM pathogenesis.

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关键词

Mesothelioma,Gene expression,Cancer genes,Biomarkers,Therapeutic targets

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