Deletion of BRCA2 exon 27 causes defects in response to both stalled and collapsed replication forks.

Tae Moon Kim,Mi Young Son,Sherry Dodds,Lingchuan Hu,Paul Hasty

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2014）

引用 24|浏览13

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摘要

•BRCA2 exon 27 (Ex27) suppresses rearrangements caused by stalled replication forks.•Ex27 suppresses rearrangements caused by collapsed replication forks.•Ex27 enables MRE11 positioning to stalled forks before collapse.

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关键词

BRCA2,RAD51,Replication fork stalling,Double strand break,Chromosomal instability

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