Triosephosphate isomerase gene promoter variation: -5G/A and -8G/A polymorphisms in clinical malaria groups in two African populations.

Mónica Guerra,Patrícia Machado,Licínio Manco,Natércia Fernandes,Juliana Miranda,Ana Paula Arez

Infection, Genetics and Evolution（2015）

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摘要

•Four SNPs variants of TPI1 were analyzed in malaria patients.•Two STRs were studied to evaluate haplotype diversity and antiquity of TPI1 promoter variants.•TPI1 -8A allele was more frequent in non-severe malaria groups.•The age estimate for -8 variant is within the period of origin of the malaria vector in Africa.•TPI1 variants could have arisen due to a selective advantage against malaria.

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关键词

Human malaria,Selection signatures,Triosephosphate isomerase-deficiency,TPI1 gene promoter variants

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