Notch is a direct negative regulator of the DNA-damage response

Jelena Vermezovic,Marek Adamowicz,Libero Santarpia,Alessandra Rustighi,Mattia Forcato, Caterina Lucano,Lucia Massimiliano,Vincenzo Costanzo,Silvio Bicciato,Giannino Del Sal,Fabrizio d'Adda di Fagagna

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2015）

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摘要

ys in both C. elegans and human cells show that Notch interacts with ATM kinase to inhibit the DNA-damage response and that Notch activity is inversely correlated with ATM activation in breast cancer cells.

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nature structural and molecular biology, science

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