Visceral Adipose Tissue Is Associated With Microstructural Brain Tissue Damage
OBESITY(2015)
摘要
ObjectiveObesity has been associated with microstructural brain tissue damage. Different fat compartments demonstrate different metabolic and endocrine behaviors. The aim was to investigate the individual associations between abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and microstructural integrity in the brain.MethodsThis study comprised 243 subjects aged 65.46.7 years. The associations between abdominal VAT and SAT, assessed by CT, and magnetization transfer imaging markers of brain microstructure for gray and white matter were analyzed and adjusted for confounding factors.ResultsVAT was associated with normalized MTR peak height in gray ( -0.216) and white matter ( -0.240) (both P<0.01) after adjustment for confounding factors. After adjustment for sex, age, and descent, SAT was associated with normalized MTR peak height in gray and white matter, but not after additional correction for BMI, hypertension, current smoking, statin use, and type 2 diabetes (respectively, -0.055 and 0.035, both P>0.05). Stepwise linear regression analysis showed that only VAT was associated with normalized MTR peak height in gray and white matter (both P<0.001).ConclusionsOur data indicate that increased abdominal VAT rather than SAT is associated with microstructural brain tissue damage in elderly individuals.
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关键词
visceral adipose tissue,adipose tissue,brain tissue
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