Men's Health Is Not Affected by Their Mothers' Intrahepatic Cholestasis of Pregnancy.

Little is known about the effects of mother's intrahepatic cholestasis of pregnancy (ICP) on the health of sons born to these mothers. The purpose of the present study was to explore the health of sons born to mothers with ICP. The study design was a retrospective study of ICP mothers' sons. In the region of Tampere University Hospital in Finland, 365 sons of mothers with ICP during 1969 to 1988 and 617 sons of mothers without ICP were sent a questionnaire in 2010. The response rates were 37.8% (n = 138) and 36.6% (n = 226), respectively. Only minor differences were reported between the two groups. Self-evaluated health was similar. There were no significant differences between the groups regarding symptoms and complaints, diagnosed diseases, mental health, and use of medicines. Cough was 10.8 percentage points less common among ICP mothers' sons than among controls (p=.034). Urticaria was more common among ICP mothers' sons, the difference in percentage points being 2.2 (p=.026). In general, a mother's ICP does not affect her son's health.