Effect of adenosine system in the action of oseltamivir on behavior in mice.

Hidemori Uchiyama,Makoto Hiromura,Tomonori Shiratani,Hiroaki Kuroki,Sinichiro Honda,Kazuhiro Kosako,Shinji Soeda,Kazuhide Inoue,Akihisa Toda

Neuroscience Letters（2015）

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摘要

•Caffeine (10mg/kg) in combination with oseltamivir for 1 day increased ambulation.•Caffeine (30mg/kg) in combination with oseltamivir for 3 days increased ambulation.•These enhancements were inhibited by an adenosine A2 receptor agonist.•Oseltamivir carboxylate for 1 day (0.3μg/mouse) alone increased ambulation.

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关键词

Oseltamivir (Tamiflu®),Oseltamivir metabolite,Caffeine,Adenosine receptor

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