9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors.

Kurt Zimmermann,Xiaopeng Sang,Harold A Mastalerz,Walter L Johnson,Guifen Zhang,Qingjie Liu,Douglas Batt,Louis J Lombardo,Dinesh Vyas,George L Trainor,John S Tokarski,Matthew V Lorenzi,Dan You,Marco M Gottardis,Jonathan Lippy,Javed Khan,John S Sack,Ashok V Purandare

Bioorganic & Medicinal Chemistry Letters（2015）

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摘要

The discovery, synthesis, and characterization of 9H-carbazole-1-carboxamides as potent and selective ATP-competitive inhibitors of Janus kinase 2 (JAK2) are discussed.

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关键词

JAK2,JAK,JAK family selectivity,JAK1,JAK3,TYK2,Myeloproliferative disorders,Myeloproliferative neoplasms

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