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Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides.

BIOCHEMISTRY, no. 11 (2005): 4196-4203

Cited by: 46|Views3
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Abstract

Human estrogen-related receptor 2 (hERR2, ESRRB, ERR beta, NR3B2) belongs to a class of nuclear receptors that bind DNA through sequence-specific interactions with a 5'-AGGTCA-3' estrogen response element (ERE) half-site in the major groove and an upstream 5'-TNA-3' site in the minor groove. This minor groove interaction is mediated by a ...More

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