Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity
Nature(2015)
摘要
PIK3CA mutations are associated with distinct types of human breast cancers but the cellular origin and mechanisms responsible for this heterogeneity were unclear; here, using a genetic approach in mice, PIK3CA mutations are shown to activate a genetic program directing multiple cell fates in normally lineage-restricted cell types.
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关键词
Breast cancer,Mammary stem cells,Oncogenes,Tumour heterogeneity,Science,Humanities and Social Sciences,multidisciplinary
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