Directional dominance on stature and cognition in diverse human populations
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Weir,Markku Laakso,Vilmundur Gudnason,Atsushi Takahashi,John C. Chambers,Jaspal S. Kooner,David P. Strachan,Harry Campbell,Joel N. Hirschhorn,Markus Perola,Ozren Polašek,James F. Wilson
Nature（2015）
引用 182|浏览333
摘要
n analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide homozygosity and four complex traits (height, lung function, cognitive ability and educational attainment); in each case increased homozygosity associates with a decreased trait value, but no evidence was seen of an influence on blood pressure, cholesterol, or ten other cardio-metabolic traits.
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关键词
Inbreeding, Evolutionary genetics, Quantitative trait loci
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