Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

Lu Long,Mark L Ormiston,Xudong Yang,Mark Southwood,Stefan Gräf,Rajiv D Machado,Matthias Mueller,Bernd Kinzel,Lai Ming Yung,Janine M Wilkinson,Stephen D Moore,Kylie M Drake,Micheala A Aldred,Paul B Yu,Paul D Upton,Nicholas W Morrell

Nature Medicine（2015）

引用 399|浏览18

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摘要

BMP9 activates signaling through the BMPR-II receptor in endothelial cells and reverses established disease in three animal models of pulmonary hypertension, thus pointing to a potential new treatment for this disease.

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关键词

Translational research,Vascular diseases,Biomedicine,general,Cancer Research,Metabolic Diseases,Infectious Diseases,Molecular Medicine,Neurosciences

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