Transcriptional regulator PRDM12 is essential for human pain perception

Ya-Chun Chen,Michaela Auer-Grumbach,Shinya Matsukawa, Manuela Zitzelsberger,Andreas C Themistocleous,Tim M Strom,Chrysanthi Samara,Adrian W Moore,Lily Ting-Yin Cho,Gareth T Young, Caecilia Weiss,Maria Schabhüttl,Rolf Stucka,Annina B Schmid,Yesim Parman,Luitgard Graul-Neumann,Wolfram Heinritz,Eberhard Passarge,Rosemarie M Watson,Jens Michael Hertz,Ute Moog,Manuela Baumgartner,Enza Maria Valente,Diego Pereira,Carlos M Restrepo,Istvan Katona,Marina Dusl,Claudia Stendel,Thomas Wieland,Fay Stafford,Frank Reimann,Katja von Au,Christian Finke,Patrick J Willems,Michael S Nahorski,Samiha S Shaikh,Ofélia P Carvalho,Adeline K Nicholas, Gulshan Karbani,Maeve A McAleer,Maria Roberta Cilio,John C McHugh,Sinead M Murphy,Alan D Irvine,Uffe Birk Jensen,Reinhard Windhager,Joachim Weis,Carsten Bergmann,Bernd Rautenstrauss,Jonathan Baets,Peter De Jonghe,Mary M Reilly, Regina Kropatsch,Ingo Kurth,Roman Chrast,Tatsuo Michiue,David L H Bennett,C Geoffrey Woods,Jan Senderek

Nature genetics（2015）

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摘要

Geoffrey Woods, Jan Senderek and colleagues show that biallelic mutations in PRDM12 cause congenital insensitivity to pain. They further show that PRDM12 is expressed in nociceptors and their progenitors and participates in sensory neuron development in Xenopus .

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关键词

Medical genetics,Peripheral neuropathies,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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