Cis-3-hexenol and trans-2-hexenal mixture prevents development of PTSD-like phenotype in rats.

Yoshikazu Nikaido,Junko Yamada,Keisuke Migita,Yuko Shiba,Tomonori Furukawa,Toshihiro Nakashima,Shinya Ueno

Behavioural Brain Research SreeTestContent1（2016）

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摘要

•Daily, not acute, green odor (GO) presentation facilitated fear extinction.•Daily GO presentation prevented development of PTSD-like phenotype after fear conditioning.•Chronic paroxetine treatment improved PTSD-like phenotype but not fear expression.•Chronic p-chlorophenylalanine (PCPA) treatment inhibited fear extinction but not PTSD-like phenotype.•The alleviative effects of GO were masked by paroxetine and abolished by PCPA.

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关键词

Post-traumatic stress disorder (PTSD),cis-3-Hexenol,trans-2-Hexenal,Paroxetine,p-Chlorophenylalanine

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