Pre-sensitization to HY-antigens in female donors prior to transplant is not associated with male recipient post-transplant HY-antibody development nor clinical outcomes.

Hideki Nakasone,Bita Sahaf, Liguang Tian,Tong Wang,Michael D Haagenson,Kelsi Schoenrock,Spenser Perloff,Christine E Ryan,Fang Wu,Stephen R Spellman,Stephanie J Lee,Jerome Ritz,David B Miklos

HAEMATOLOGICA（2016）

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摘要

It has been shown that chronic graft- versus -host disease (cGVHD) incidence is significantly increased in male recipients receiving allogeneic hematopoietic cell transplant from female donors (F→M HCT).[1][1],[2][2] B cell immunity plays a critical role in cGVHD development,[3][3],[4][4] and we

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关键词

allogeneic hematopoietic transplantation,bone marrow transplantation,graft versus host disease (GVHD),HY antigen,sex mismatch transplantation

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