Aerosolized Non-viral Nucleic Acid Delivery in the Vaginal Tract of Pigs.
Pharmaceutical research(2015)
摘要
The human pathogen Chlamydia trachomatis is worldwide the leading cause of bacterial sexually transmitted disease. Nasal or vaginal nucleic acid vaccination is a promising strategy for controlling genital Chlamydia trachomatis infections. Since naked nucleic acids are generally not efficiently taken up by cells, they are often complexed with carriers that facilitate their intracellular delivery.
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关键词
plasmid DNA,mRNA,aerosolization,vaginal administration,non-viral gene delivery complexes
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