The vitamin D-dependent transcriptome of human monocytes.

Antonio Neme,Veijo Nurminen,Sabine Seuter,Carsten Carlberg

The Journal of Steroid Biochemistry and Molecular Biology（2016）

引用 31|浏览12

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摘要

•The transcriptome of 1,25(OH)2D3-stimulated THP-1 cells (determined by RNA-seq) is reviewed.•Primary and secondary vitamin D target genes being up- and down-regulated were related to changes in the epigenome.•Epigenomic and transcriptomic responses of THP-1 cells to 1,25(OH)2D3 represent a master example of the impact of vitamin D on human physiology.

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1,25(OH)2D3 or 1,25D,25(OH)D3,CAMP,CCL,CD,ChIP-seq,CTCF,CYP,DR3,FAIRE-seq,FC,FCER2,FDR,HBEGF,HDAC,IGV,PBMCs,RNA-seq,RXR,TLR,TSS,VDR

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