Synthesis and antiproliferativeactivity of new vinca alkaloids containing an α,β-unsaturated aromatic side chain.

Quoc Anh Ngo,Le Anh Nguyen,Ngoc Binh Vo,Thuy Hang Nguyen,Fanny Roussi,The Hung Nguyen,Van Tuyen Nguyen

Bioorganic & Medicinal Chemistry Letters（2015）

引用 7|浏览11

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摘要

A new series of vinca-alkaloids derivatives containing various α,β-unsaturated aromatic side chains was synthesized. Four new vinca-alkaloids derivatives showed selective cytotoxicities against KB tumor cell lines with IC50 value below 0.1μM, thus comparable with vinblastine.

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关键词

Vinca alkaloids,Sarcodictyins,Cytotoxicity,Tubulin

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