Impact of subsequent screening episodes on the positive predictive value for advanced neoplasia and on the distribution of anatomic subsites of colorectal cancer: A population-based study on behalf of the French colorectal cancer screening program.

•PPV for detection for advanced neoplasia fells after the first screening episodes.•Detection of AA in the proximal colon increase with repeated screening.•Detection of adenocarcinoma in the proximal colon increase with repeated screening.•We underline the need to reinforce the population’s awareness of the importance of regular consistent screening.•Further studies should distinguish prevalent screening from incident screening episodes.