Efficacy of parainfluenza virus 5 (PIV5)-based tuberculosis vaccines in mice.

Zhenhai Chen,Tuhina Gupta,Pei Xu,Shannon Phan,Adrian Pickar,Wilson Yau,Russell K Karls,Frederick D Quinn,Kaori Sakamoto,Biao He

Vaccine（2015）

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摘要

•We developed a novel TB vaccine that is as effective as BCG in mice.•Using BCG-prime and novel-vaccine boost, we further enhanced efficacy of the vaccine candidates.•We have for the first time shown that PIV5 is effective as a vaccine vector for bacteria pathogen.

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关键词

Parainfluenza virus 5,Mycobacteria tuberculosis,Vaccine,Antigen 85A,Antigen 85B,BCG

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