Dearomatization of -Unsubstituted -Naphthols

This Account summarizes the highly appealing dearomatization reactions of beta-naphthols for the synthesis of highly functionalized, three-dimensional structures starting with simple planar aromatic compounds. The reactions are categorized mainly from the viewpoint of the construction of carbon-hydrogen, carbon-carbon, and carbon-hetero bonds (C-N/O, C-Cl, C-F) at the alpha-position of beta-naphthols. The dearomatized products play an important role in organic synthesis and materials science.IntroductionConstruction of Carbon-Hydrogen Bonds at the alpha-Position of beta-NaphtholsConstruction of Carbon-Carbon Bonds at the alpha-Position of beta-NaphtholsConstruction of Carbon-Nitrogen/Oxygen Double Bond at the alpha-Position of beta-NaphtholsConstruction of Carbon-Carbon and Carbon-Oxygen Bonds at the alpha-Position of beta-NaphtholsConstruction of Carbon-Halogen Bonds at the alpha-Position of beta-NaphtholsConclusion