Contrast-enhanced transrectal ultrasonography for the detection of diffuse prostate cancer.

•CE-TRUS may improve cancer detection over baseline TRUS imaging for the diagnosis of diffuse prostate cancer.•CE-TRUS detects diffuse prostate cancer without an obvious focal mass on routine TRUS or clinical examination.•CE-TRUS may help identify patients who do not need a repeat biopsy or undergo systematic 12-core invasive sampling biopsies.