Using patient serum to epitope map soybean glycinins reveals common epitopes shared with many legumes and tree nuts.

•The IgE-binding B-cell epitopes of two similar soybean glycinin subunits (Gly m 6) are described.•Three-dimensional modeling of the glycinin hexamers located most epitopes on the exposed surfaces.•Comparison with other plant 11S storage protein sequences revealed one dominant and several shared epitopes.•Common epitope hot spots are often shared between plant storage proteins from diverse families.