Elevated levels of Interleukin (IL)-33 induce bone pathology but absence of IL-33 does not negatively impact normal bone homeostasis.

Angela J Okragly,Matthew J Hamang, Emily A Pena,Hana E Baker,Heather A Bullock,Jonathan Lucchesi,Andrea P Martin,Y Linda Ma,Robert J Benschop

Cytokine（2016）

引用 9|浏览16

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摘要

•The role of IL-33 in bone homeostasis is unclear from existing literature.•Absence of IL-33 does not negatively impact normal bone homeostasis.•Overexpression of the cytokine form of IL-33 contributes to pathological bone loss.

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关键词

IL-33,Bone,Biomechanics,Genetic deficient mice,Aging

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