Changing characteristics of statin-related cIMT trials from 1988 to 2006.

•Factors related to variability of cIMT changes in statin trials over time were assessed.•Studies before 2000 had higher baseline cIMT and LDL-C, and larger cIMT changes than after 2000.•Study timing and duration, and LDL-C reduction were related to heterogeneity in cIMT changes.•These trends are consistent with increased treatment/control of LDL-C levels in recent years.•Such factors should be considered when designing future cIMT lipid-lowering trials.