Epsilon-Globin Expression Is Regulated By Suv4-20h1

Yadong Wang,Gerhard Rank, Zhuchen Li, Ying Wang,Junyi Ju,Alexander Nuber,Yupeng Wu,Ming Liu,Min Nie,Feifei Huang,Loretta Cerruti,Chi Ma,Renxiang Tan, Gunnar Schotta,Stephen M. Jane,Changjiang K. Zeng,Quan Zhao

HAEMATOLOGICA（2016）

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摘要

Research efforts to establish therapeutic modalities for treating sickle cell disease (SCD) and β-thalassemia have been hindered by our incomplete understanding of the developmental regulation of human β-like globin gene expression. It has been demonstrated that increased embryonic globin (e-

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关键词

epsilon-globin,SUV4-20h1,histone methylation,DNA methylation,beta-thalassemia

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