Epigenomic annotation of gene regulatory alterations during evolution of the primate brain
NATURE NEUROSCIENCE(2016)
摘要
Gene-regulatory elements are drivers of evolutionary divergence, yet where these are located and which are evolutionarily relevant is unclear. In this work, large-scale epigenomic analysis of human, rhesus and chimpanzee brain tissue allowed the identification of human-specific gene-regulatory changes that contributed to the emergence of the human brain.
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关键词
Evolution,Genetics of the nervous system,Epigenetics in the nervous system
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