Evaluation of Synurus deltoides for antioxidant, antimicrobial, and anti-proliferative activities using In vitro assays

The antioxidant, antimicrobial, and anti-proliferative activities of water and ethanol extracts from leaves of Synurus deltoides (SD) were investigated. Extracts showed strong reductive powers, nitrite-scavenging activities, DPPH, ABTS, hydroxyl, and superoxide radical scavenging activities, and DNA damage prevention activities. SD extracts also showed strong cellular antioxidant activities in a dose-dependent manner with IC 50 values of 0.93 and 0.65 mg/mL for water and ethanol extracts, respectively. Antimicrobial activities were evaluated against 4 microorganisms. SD extracts showed high inhibitory activities against Pseudomonas aeruginosa and Staphylococcus aureus . The anti-proliferative activity was dose-dependent against human colon adenocarcinoma (HT-29) and mouse rectum carcinoma cells (CMT-93). In addition, HPLC analyses of SD leaf extracts revealed the presence of different phenolic compounds. SD can be considered as a source of functional foods and pharmaceuticals.