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The Effect Of Erythropoietin On Bleomycin-Induced Pulmonary Fibrosis In Rats

Drosos Tsavlis, Evangellia Spandou, Kokkona Koliakoskouzi,Dimitrios Koutsonikolas,Anna Tzoumaka,Constantina Simeonidou,Ioannis Angomachalelis, Solon Bountzioukas

CHEST(2007)

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Abstract
PURPOSE: Pulmonary fibrosis (PF) is characterized by fibroblasts proliferation, excessive deposition of collagen and extracellular matrix remodeling due to inflammatory processes, such as reactive oxygen species’ generation and apoptosis. Erythropoietin (EPO) is a multiple functional cytokine with anti-oxidative, anti-inflammatory and anti-apoptotic properties. Aim of this study was to examine the effects of EPO on bleomycin (BLM)-induced lung fibrosis in rats.
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Key words
erythropoietin,bleomycin-induced
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