Damaged DNA-binding protein down-regulates epigenetic mark H3K56Ac through histone deacetylase 1 and 2

Qianzheng Zhu,Aruna Battu,Alo Ray,Gulzar Wani,Jiang Qian,Jinshan He,Qi-en Wang,Altaf A. Wani

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2015）

引用 29|浏览14

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摘要

•HDAC1 and HDAC2 co-localize with UV radiation-induced DNA damage sites.•HDAC1 translocation to chromatin is dependent on DDB2 function.•HDAC1 and HDAC2 are involved in H3K56Ac deacetylation.•H3K56Ac deacetylation requires DDB1 and DDB2 but not XPA or XPC functions.•HDAC1/2 depletion decreases XPC ubiquitination and local γH2AX accumulation.

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关键词

Histone post-translational modifications,Nucleotide excision repair,Damaged DNA-binding protein 2,Histone deacetylases,Acetylated histone H3 lysine 56,Xeroderma pigmentosum group E

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