Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis(2015)

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摘要
•We overexpressed APE1 in vitro and in vivo to assess changes in mutagenesis.•Overexpressing APE1 protects against spontaneous and induced mutations in vitro.•Wild-type mice display an age-related increase in spontaneous germline mutagenesis.•Overexpression of APE1 protects germ cells against the germline mutagenesis.
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关键词
Paternal Age,DNA repair,APEX1,Mutagenesis,LacI,Spermatogenesis
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