Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice

Jamila R. Sanchez, Traci L. Reddick,Marissa Perez,Victoria E. Centonze,Sankar Mitra,Tadahide Izumi,C. Alex McMahan,Christi A. Walter

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2015）

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摘要

•We overexpressed APE1 in vitro and in vivo to assess changes in mutagenesis.•Overexpressing APE1 protects against spontaneous and induced mutations in vitro.•Wild-type mice display an age-related increase in spontaneous germline mutagenesis.•Overexpression of APE1 protects germ cells against the germline mutagenesis.

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关键词

Paternal Age,DNA repair,APEX1,Mutagenesis,LacI,Spermatogenesis

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