Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing

Arun Upadhyay,Ayeman Amanullah,Deepak Chhangani,Ribhav Mishra,Amit Mishra

Ageing Research Reviews（2015）

引用 17|浏览18

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摘要

•This review emphasizes role of crucial E3 ubiquitin ligases in ageing and neurodegeneration.•Neurons are affected by risk factor such as aggravate abnormal protein aggregation.•How few E3 ubiquitin ligases provide quality cytoprotection against damaged proteins?•E3 ubiquitin ligases insights can improve diagnosis and treatment strategies of ageing.•New challenges and emerging promises in the future treatment of neurodegeneration.

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关键词

AAD,4-PBA,6-OHDA,ABCG5/8,AD,AIB1,AIP4,AMPA,APP,Arc,AS,ASIP,ATF6α,Aβ,BiP,BMP,C3HC4,CAG,cAMP,CBP,CD3-δ,cFLIP,CFTR,CHD,cIAP1,CREB,CtmPrP,CXCR4,cyPrP,DA,DAR2,DERL2,DNA,DTX,DVL,E1,E2,E3,E6-AP,EGFR,ER,ERAD,ErbB4,ERQC,ESCRT-I,FCCH,FLICE,Gcase,GABAB3,GDP,GDU1,Gli1,Gp78,GRP94,GTP,HB,HD,HECT,Herp,HMG-CoA,HRD1,Hsp40,Hsp70,Htt,IAD,IL-1β,IRE1,ITCH,JNK,Kar2P,LAPTM5,LATS1,LC3,LOG2,LR,LSDs,LTP,MC1r,MGRN1,MHC,NaCl,NCC,NF-κβ,NGF,NHK,NOD2,NORE1,Nrf2,OS-9,Pael-R,PD,PDB,PLC-γ1,PML,PPxY,PRD,PrPC,PrPSC,PSAP,PSD95,QC,RA,RAS,RASSF5,RD21,Rer1,RING,RIP2,RMA1,RML,RNF157,SCA1,SCCH,SEC62,SEL1L,SHH,SMAD,SNC,SNX9,SOD1,SOX9,SQSTMI,SYVN1,TALTSG101,TBPTATA,TCR-α,TGF-β,TJ,TNFα,TSG101,TXNIP,UBC,UBE3A,UEV,UFD,UPD,UPR,UPS,WFS1,YOS9p,αCaMK11

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