176 Elevation of 90 minutes plasma glucose during oral glucose tolerance testing predicts development of cystic fibrosis related diabetes and lung function decline

Objectives Recent studies have shown the effect of cystic fibrosis related diabetes (CFRD) on nutritional status and lung function of patients with CF. The aim of our study was to determine the prevalence of CFRD in Slovenian children with CF and the influence of hyperglycemia on their lung function and nutritional status. Methods Data from all Slovenian children with CF were collected. A diagnosis of CFRD was made based on oral glucose tolerance testing (OGTT) and continuous glucose monitoring. The highest level of blood glucose (BG) and the time during the OGTT were evaluated. Nutritional status and lung function of patients with CFRD were determined and compared to CF patients without CFRD. Results A total of 70 patients with a median age of 10.97 (0.9–22.3) years are managed in our Center. Twelve were diagnosed with CFRD (10 girls and 2 boys; median age 15.97 (9.21–18.59) years. The prevalence of CFRD was 17.1%. In 9 the BG levels u003e11.1 mmol/l at 90 ; during the OGTT were observed. The median value ob glycosylated hemoglobin (HbA1c) at diagnosis was 6.15 (5.6–6.8)%. The median FEV1 was 62% of predicted value and BMI 18.2 (12.4–21.7) kg/m 2 which is the 21 st percentile for age and gender. In patients with CFRD the median FEV1 was 24% lower compared with the rest of our CF patients while there was no significant difference in their BMI. Conclusions The prevalence of CFRD in our Center is comparable to the published data of CF patients of the same age group. Most of the CFRD patients had the highest BG level at 90 ; during OGTT. CFRD was associated with decline in lung function while it had no significant impact on nutritional status of our patients.