Abstract W P329: Oxygen Desaturation Index by Apnea Link as Prognostic Factor in Acute Ischemic Stroke

Objective: To determine the association between the Apnea-Hypopnea Index (AHI) and the Oxygen Desaturation Index (ODI) with the functional outcome in Acute Ischemic Stroke Patients and describe the prevalence of sleep respiratory disorders in this population. Methods: Patients with Acute Ischemic Stroke and NIHSS≤20, within 5 days of admission were tested with Apnea Link device. We analyzed demographic, clinical, and functional characteristics (mRS, NIHSS and Barthel) at outcome, 3 and 6 months after discharge. Results: We included 111 patients, 62% male, with 64.4 ± 12 years-old and Body Mass Index (BMI) of 27 (18-60). NIHSS was ≤12 in 82% of patients. 30% had an AHI ≥30. Patients were divided in 2 groups according to mRS score (0-3 and ≥4) at discharge, 3 and 6 months follow-up. No statistically significant difference was found between groups regarding demographic, clinical and risk factors with symptoms associated with sleep disorders. At 6 months, ODI were associated with a worse functional outcome (p=0.017), but not with AHI (p=0.157). Multivariate analysis revealed that NIHSS (p=0.01) and the ODI (p=0.021) were associated with a mRS ≥4 at 6 months follow-up after adjusting for age, gender and BMI. Conclusions: There is a high prevalence of sleep respiratory disorders in our population. The correlation found between ODI and the mRS at the 6 months follow-up suggests a prognostic potential in Ischemic Stroke.