Increased Serum Levels of the Notch Ligand DLL1 Are Associated With Diastolic Dysfunction, Reduced Exercise Capacity, and Adverse Outcome in Chronic Heart Failure

H M Norum,Lars Gullestad,Aurelija Abraityte,Kaspar Broch,Svend Aakhus,Pal Aukrust,Thor Ueland

Journal of Cardiac Failure（2016）

引用 23|浏览11

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摘要

•Serum levels of the Notch ligand DLL1 are elevated in chronic heart failure.•High DLL1 levels are associated with diastolic dysfunction.•High DLL1 levels are associated with reduced exercise capacity.•High DLL1 levels are associated with increased risk of adverse outcome.

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关键词

Chronic heart failure,diastolic dysfunction,Notch signaling,DLL1,exercise capacity,adverse outcome

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