Chronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release

Mattia Volta,Stefano Cataldi,Dayne Beccano-Kelly,Lise Munsie,Igor Tatarnikov,Patrick Chou,Sabrina Bergeron,Emma Mitchell, Roscoe Lim,Jaskaran Khinda, Alejandro Lloret,C.Frank Bennett, Carmela Paradiso,Michele Morari,Matthew J. Farrer,Austen J. Milnerwood

Parkinsonism & Related Disorders（2015）

引用 41|浏览46

暂无评分

摘要

•Genetic deletion of LRRK2 is benign in vivo.•Acute knockdown of striatal LRRK2 does not affect behavior or dopamine terminals.•Overexpression of WT-LRRK2 causes lasting behavioral deficits.•Overexpression of G2019S-LRRK2 leads to a progressive motor and cognitive phenotype.•G2019S-LRRK2 overexpression reduces sensitivity to D2-mediated inhibition of dopamine release.

查看译文

关键词

Parkinson's disease,LRRK2,Genetic models,Behavior,Cognition,Synaptosomes

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要